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Agammaglobulinemia Associated with Pernicious Anemia and Diabetes Mellitus

EDWARD C. LEWIS II, M.D.; HARVEY E. BROWN Jr., M.D.
AMA Arch Intern Med. 1957;100(2):296-299. doi:10.1001/archinte.1957.00260080122024.
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Agammaglobulinemia, or hypogammaglobulinemia, as it is now being referred to by some authors, was first described as a clinical entity in 1952.1 Since that time there have been a number of excellent papers on this subject,2-4 but the total number of reported cases is still relatively small. It is not the purpose of this paper to review this subject of agammaglobulinemia, but rather to present a case in which agammaglobulinemia, pernicious anemia, and diabetes mellitus are present.

Abnormalities of the hemopoietic system are not infrequently seen associated with agammaglobulinemia,4-6 but this appears to be the first case associated with pernicious anemia. There appears to be one previously reported case associated with diabetes mellitus.7

Agammaglobulinemia is a disease in which γ-globulin is absent or diminished in the serum, with the result that the person so afflicted has little or no resistance to diseases normally combated by immune

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