0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Influence of Promazine and Methylphenidate on Cerebral Hemodynamics and Metabolism

WILFRED R. EHRMANTRAUT, M.D.; JAMES G. SHEA, M.D.; HOWARD E. TICKTIN, M.D.; JOSEPH F. FAZEKAS, M.D.
AMA Arch Intern Med. 1957;100(1):66-69. doi:10.1001/archinte.1957.00260070080008.
Text Size: A A A
Published online

Promazine, a new phenothiazine derivative, appears to offer considerable promise in the control of patients with increased psychomotor activity 1,2 as well as assisting in the management of patients with various medical emergencies.3 The exact physiological mechanism by which this drug exerts its effects is not known; however, previous studies4 have shown chlorpromazine, a somewhat similar phenothiazine derivative, to have no demonstrable effects upon total cerebral hemodynamics and oxygen utilization. It was nevertheless considered worth while to determine whether this was also true of promazine. In addition, this study afforded the opportunity to examine the clinical and quantitative cerebral effects of methylphenidate hydrochloride (an analeptic drug) alone and upon subjects to whom promazine had been previously administered.

Methods  The subjects of the present study were 21 hospital patients who had been admitted for a variety of acute illnesses but were convalescent and otherwise in reasonably good condition. They

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 11

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();