We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.

Thrombocytopenia and Renal Lesions Associated with Acetazoleamide (Diamox) Therapy

AMA Arch Intern Med. 1957;99(6):1006-1008. doi:10.1001/archinte.1957.00260060164013.
Text Size: A A A
Published online

Recently both thrombocytopenia and renal lesions similar to those produced by sulfonamides have been reported in association with the use of acetazoleamide (Diamox),1,2 a carbonic anhydrase inhibitor of sulfonamide origin used as a diuretic. Both types of reaction occurred in the following case.

Report of Case  A 61-year-old white man was admitted to the Veterans Administration Hospital, Philadelphia, on March 5, 1956, with a history of recurrent peripheral edema of nine months' duration. One month before admission the edema became persistent and progressive. There were no cardiac or pulmonary complaints, and review of symptoms by systems was essentially negative. Except for edema of the legs, scrotum, and presacral region, the physical examination was within normal limits. The blood pressure was 130/70. Study of the urine disclosed a specific gravity fixed at 1.010. There was marked proteinuria, and the urinary sediment contained occasional casts, red blood cells, and white blood


Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 25

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.