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Cryptococcal Infection Treated with 2-Hydroxystilbamidine in a Patient with Boeck's Sarcoid

AMA Arch Intern Med. 1957;99(5):736-743. doi:10.1001/archinte.1957.00260050064008.
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Cryptococcal infections (Torula) in man are uncommon, most cases having appeared in the literature as individual reports. The disease does not appear to be endemic, having a generalized distribution throughout the world. The majority of cases in the literature have been of the meningeal form; however, a few reports have presented only pulmonary, cutaneous, or osseous involvement. A variety of therapeutic agents have been employed with generally disappointing results. Evaluation of therapy has been made difficult because of scattered, individual case reports as well as spontaneous remissions seen in this disease. We therefore urge the report of all such cases and present one of our own. In presenting this case we have two considerations; therapy with 2-hydroxystilbamidine and the significance of a coexisting granulomatous process.

Report of a Case 

History.  —This 27-year-old Negro male veteran was apparently well until November, 1952, when he was hospitalized in Japan for the treatment


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