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Clinical Syndromes Produced by Isolated Dysfunctions of the Renal Tubule

AMA Arch Intern Med. 1957;99(2):172-175. doi:10.1001/archinte.1957.00260020008002.
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It is certain that the speakers to come before the Section on Experimental Medicine will present differing views concerning the hypertension problem, but it seems equally certain that none of them will dare to ignore the kidney. Until the present confusion subsides no one can say whether the chief culprit will be caught lurking in the nervous system, the adrenal cortex, the electrolyte panel, or the kidney, but it is hard to deny that renal epithelium shares the guilt.

The responsible processes are of course not yet understood, and opinion is therefore sharply divided between the "hyperrenalists" on the one hand, who believe that the kidney secretes an excessive amount of pressor and vasopathic material, and the "renoprivalists" on the other hand, who note how difficult it is to produce endocrine hypertension with-out first reducing kidney mass. Quite possibly both views are right, in that under circumstances not yet defined


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