The Mechanism and Significance of Protein Excretion by the Normal Kidney

AMA Arch Intern Med. 1956;98(6):801-806. doi:10.1001/archinte.1956.00250300119013.
Text Size: A A A
Published online

The supposition that the glomerular filtrate is protein-free is based on the classical experimental studies of Wearn and Richards.1 They found glomerular fluid, obtained by micropuncture from Bowman's capsule, to be "protein free" or at least to contain less than 30 mg. per 100 ml. of protein, which was the least amount that could be detected by the methods at their disposal. As Addis2 has pointed out, this supposition might be readily accepted were it not that the volume of glomerular filtrate in man is approximately 180,000 ml. per 24 hours, so that even if the protein concentration was as little as 10 mg. per 100 ml., 18,000 mg. would pass through the membrane daily. Considerations of this sort stimulated workers in the field, so that during the past 10 years our knowledge of the passage of proteins through the kidney has advanced to the point where a


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.