This booklet is a collection of twenty papers read at the first symposium of the Collegium Internationale Allergologicum in London, October, 1954. The subject material is diversified, but almost half of the papers deal with histamine, antihistaminics, or adrenal steroids. These are comprehensive and well supported by bibliographic and original data.
The immunological mechanisms in allergic disease are reviewed by Prausnitz. It is evident that only limited advances have been made in identification and characterization of the reagin since his historic demonstration of its skin-sensitizing characteristic by passive transfer in 1921. The absence of a reference to the work of Cooke and Loveless in his discussions of the blocking antibody is conspicuous in an otherwise well-documented paper. This is especially so, since he made the statement that blocking antibodies have a higher affinity for the cell than the reagins, which is contrary to the extensive studies of Cooke and Loveless,