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ARTICLE |

LOEFFLER'S SYNDROME WITH CARDIAC INVOLVEMENT

JOHN T. LECKERT, MC
AMA Arch Intern Med. 1956;98(4):510-516. doi:10.1001/archinte.1956.00250280112015.
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LOEFFLER first reported five cases of transient pulmonary infiltration associated with eosinophilia in 1932.1 The occurrence of cardiac involvement with pulmonary infiltrations and eosinophilia has been reported in one case of Mark 2 and in the case of Schwartz.3 Mark's case had an extensive infiltration throughout the left lung. A bronchogram was attempted on the left. During the installation of the local anesthetic, the patient had a coughing spasm associated with shortness of breath and what was interpreted as acute dilation of the heart. This patient's illness apparently extended over a period of at least one year, and it was five months before the cardiac size returned to normal. Schwartz's case was characterized by multiple organ involvement including allergic rhinitis, bronchial asthma, anemia, purpura, arthralgia, polyneuritis, subcutaneous nodules, albuminuria, cardiac hypertrophy, and right bundle-branch block. The patient was ill for 18 months, and there was residual cardiac hypertrophy and right bundle-branch block. Schwartz

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