Coccidioidomycosis is usually an acute relatively mild, self-limited illness. However, a very few cases progress to the highly fatal disseminated phase of the disease. Another small per cent show persistent pulmonary residuals without dissemination, which are mostly asymptomatic. This is a regional disease. However, with rapid transportation readily available to the public and with large numbers of military personnel having been trained and stationed in endemic areas during and following World War II, physicians throughout the United States might expect to encounter these pulmonary residuals. Failure to recognize these lesions often results in the making of an incorrect diagnosis of tuberculosis or other serious pulmonary disease, with the institution of prolonged ill-advised therapeutic measures and the imposition of considerable hardship on the patient. Therefore, it is important for all physicians in the United States to be aware of the diagnostic features and the prognostic implications of these residual pulmonary lesions.