Renal osteodystrophy may be defined as bone disease caused by chronic renal insufficiency. The skeletal changes may include osteomalacia, osteoporosis, and osteosclerosis or a combination of these. The changes may also be identical with those of osteitis fibrosa generalisata due to hyperparathyroidism.
In this short paper we are not concerned with the mechanism of production of the osteodystrophy, which appears to be as yet ill-understood, but rather with the remarkably constant clinical picture shown by the three cases presented here. It is to emphasize that in the short period of six months we have seen three new cases, although the disease is usually considered to be rare, and to indicate the value of bone biopsy that we present this report. It seems quite likely that many cases of renal osteodystrophy in adults are overlooked and that minor or moderate degrees of the condition are commoner than is generally supposed.