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ARTICLE |

SPRUE WITH BLEEDING FROM HYPOPROTHROMBINEMIA

MICHAEL J. MOORE, M.D.; WILLIAM H. STRICKLAND, M.D.; ROBERT W. PRICHARD, M.D.
AMA Arch Intern Med. 1956;97(6):814-816. doi:10.1001/archinte.1956.00250240166019.
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A WOMAN with definitely diagnosed non-tropical sprue bled from multiple sites and was admitted to North Carolina Baptist Hospital in 1954. Hypoprothrombinemia was established, and she was treated with intravenous vitamin K1 and fresh whole blood transfusions, with good results.

REPORT OF CASE  A 29-year-old white married woman was admitted on July 2, 1954, with a history of intermittent diarrhea all of her life. Six weeks before admission she developed soreness of the heels and walking difficulty followed by pain, swelling, and bluish-purple discoloration around the ankles and toes. Subsequently, pain, swelling, and bluish-purple discoloration appeared in the knees, elbows, and the right shoulder, followed by fever, gingival hemorrhage, and epistaxis for three days before admission. Menstrual flow was profuse. Confusion and delirium appeared two days before admission.

Past History.  —There had been two previous admissions, the first on Nov. 9, 1943, with watery diarrhea, fever, anorexia, and weight

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