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POLYCYTHEMIA VERA

AMA Arch Intern Med. 1956;97(5):521-523. doi:10.1001/archinte.1956.00250230015001.
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Current Status  POLYCYTHEMIA vera is one of the less unfortunate hematologic problems confronting the internist, for it is amenable to satisfactory control in a fair proportion of instances even though the cause of it is entirely unknown.This disease is in a general category of myeloproliferative disorders. To this group also belong the myeloid leukemias, agnogenic myeloid metaplasia, and myelofibrosis with myeloid metaplasia. It has long been recognized that these conditions are somehow related. While excessive erythropoiesis is the major feature of polycythemia vera, there also may be mature or immature leucocytosis of the myeloid type in the peripheral blood. Occasionally, what appears to be early chronic myelocytic leukemia changes into typical polycythemia vera. In many cases, polycythemia vera eventuates in conditions in which erythropoiesis is quantitatively normal or subnormal, and the major feature is leucocytic abnormality.In years past, this leucocytic abnormality was classed as "myelocytic leukemia," but as

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