The publication of the fifth edition of this familiar text indicates not only the growing scope and importance of clinical chemistry, but also that the authors have kept their book abreast of the new developments.
The present volume opens with a discussion of carbohydrate metabolism which is more general and more detailed than in the past. By a dynamic biochemical approach and by frequent cross references to material in later chapters the concept of a common final metabolic pathway is firmly established. Significant new research is described with a nice balance between bewildering detail and vague generalities. The central role of coenzyme A and the "two-carbon fragment" is described first as a general metabolic principle and then as a mechanism responsible for such situations as the hypercholesterolemia of diabetes, etc. The glucagon-insulin system is compared with and also differentiated from the epinephrine-insulin system. Much of the clinical material on diabetes,