NO CENTURY in the history of medicine has seen such revolutionary changes in our conception of disease, especially in the realm of treatment, as has the twentieth century, particularly in the last 30 years. New discoveries have given rise to fresh approaches to diseases which hitherto were considered incurable, and many of these diseased conditions have surrendered to the combined forces of applied physiology, biochemistry, and experimental and clinical medicine. Within the last 35 years diabetes, pernicious anemia, bacterial endocarditis, septicemia, plague, typhus, and malaria have all come within the realm of curable diseases. Even in the more chronic infective conditions, such as tuberculosis and leprosy, there is a hope and an expectation of cure, which has never been experienced before. It is, therefore, with the sense of one treading on the verge of a new world that I approach this subject of leprosy and acknowledge the honor and privilege
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