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Aldosterone in Clinical Medicine — Past, Present, and Future

AMA Arch Intern Med. 1956;97(2):135-144. doi:10.1001/archinte.1956.00250200011001.
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This paper is also appearing this month in the Journal of the Michigan State Medical Society, a number devoted to honoring the Medical School of the University of Michigan. TheArchivesis happy to collaborate in this fine gesture to the notable accomplishments of this great medical school.

Among the outstanding accomplishments of this institution are the studies on aldosterone of Dr. Jerome W. Conn and his associates so modestly reported here. Paul S. Rhoads, M.D. The time has arrived for clinicians to become aware of the increasing importance in clinical medicine of aldosterone, the newly discovered adrenal cortex hormone. It has been demonstrated that increased adrenal production of aldosterone is involved in the pathogenesis of a number of very common clinical disorders. That many more diseases will be found to be associated with increased or decreased secretion of this hormone seems abundantly clear. This prediction is based not only


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