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ARTICLE |

SICKLE CELL TRAIT AND DISEASE IN PULMONARY TUBERCULOSIS

Harold A. Lyons, M.D.
AMA Arch Intern Med. 1955;96(6):833-834. doi:10.1001/archinte.1955.00250170139023.
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ABSTRACT

To the Editor:  —Dr. Weiss reported "that sickle cell trait is more than twice as common (12.6%) among tuberculous Negroes admitted to a large municipal general hospital than it is among nontuberculous Negroes admitted to the same hospital (5.3%)" and stressed the importance of his control series studied concurrently with the observed cases as well as the negative chest photofluorogram in control series. At Kings County Hospital, where the hematology division has been actively studying sickle cell anemia since 1946, we have repeatedly demonstrated the rather constant incidence of about 8% of persons with sickleable cells. An early report from this hospital is that of Watson, J.; Stahman, A. W., and Bilelle, F. P.: Am. J. M. Sc.215:419, 1949, which included 226 consecutive Negro females with a sickling incidence of 8%. More recently, since the introduction of the filter paper electrophoresis technique, we have screened large numbers

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