In 1950 Šantavý and Reichstein 1 reported the isolation of several previously unknown alkaloids from the meadow saffron (Colchicum autumnale), the source of colchicine. Subsequently the pharmacological properties of these alkaloids were investigated by Schär, Loustalot, and Gross,2 and one of the compounds, demecolcine, was found to have an antimitotic effect equivalent to that of colchicine in fibroblast cultures and considerably less toxicity in laboratory animals. Structurally, demecolcine differs from colchicine in the replacement of the acetyl group at the nitrogen by a methyl radical (Fig.).
Formulas of colchicine (left) and demecolcine (desacetylmethylcolcine) (right).
Extensive laboratory study by Schär, Loustalot, and Gross demonstrated that, in all animal species, demecolcine is considerably less toxic than colchicine. In mice, for example, the intravenous lethal dose of demecolcine is as much as 40 times greater than that of colchicine. Paradoxically, in mice demecolcine is about six times more toxic orally than intravenously
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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