Endemic Goiter: The Adaptation of Man to Iodine Deficiency.

AMA Arch Intern Med. 1955;95(5):761. doi:10.1001/archinte.1955.00250110131017.
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A real contribution to the better understanding of the physiology of the thyroid gland has been made by the authors, who studied thyroid function in 138 persons with goiters living in the province of Mendoza, Argentina. Goiter is endemic in this west central section of Argentina, where the food and water ingested by the native population is deficient in iodine. Most of the goiters encountered were nodular goiters, and most of the persons included in the study were euthyroid. Various aspects of thyroid function were studied as measured by the percent of a tracer dose of I131 collected by the gland and excreted into the urine, the serum protein-bound-iodine, and the amount of inorganic iodide excreted in the urine. Many interesting, important, and provocative observations were made in these patients by the authors, and they are set forth in the book in clear terms and a readable style. The


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