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AUTOIMMUNE HEMOLYTIC DISEASE IN ACUTE LEUKEMIA

ABRAHAM M. FRUMIN, M.D.; ALBERT KOHN, B.S.
AMA Arch Intern Med. 1955;95(2):326-327. doi:10.1001/archinte.1955.00250080148013.
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THE OCCURRENCE of autoimmune hemolytic disease in the leukemias has become increasingly recognized. It is most frequently seen in chronic lymphocytic leukemia 1 and has been described in one case of chronic granulocytic leukemia.2 We wish to present the first recorded instance in a patient with acute granulocytic leukemia.

R. B., a 26-year-old white woman, was admitted to the Albert Einstein Medical Center, Southern Division, on July 3, 1953, because of weakness and pallor. Five months previously she delivered a normal healthy child, without mishap. A diagnosis of "virus pneumonia" was made a month later because of fever and malaise. Cervical adenopathy was soon noted. A persistent anemia developed two months prior to this hospitalization, which was refractory to various hematinics. She was admitted to another institution, from which, because of inability to type and cross match her blood, she was then referred for evaluation.

Physical examination revealed

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