This monograph presents a thorough discussion of the problems of acute anuria, including detailed studies on 32 patients. The first part of this monograph is devoted to a comprehensive review of the literature on toxic and ischemic types of tubular necrosis, on the pathogenesis and mechanisms involved in anuria, and on the renal-function pattern as determined by the special clearance studies. The concept of lower nephron nephrosis is appropriately criticized in the light of Oliver's recent work.
Part 2 consists of the author's detailed studies on his clinical series. In addition to the complete battery of renal-function tests there is an interesting series of renal biopsies, some of which are compared with autopsy studies on the same patients. The lesions are clearly shown to be distributed in the proximal as well as in the distal convoluted tubules. The histological changes are not specific for the etiological diagnosis of the tubular