0
ARTICLE |

CONGENITAL HYPOPROTHROMBINEMIC STATES

ARMAND J. QUICK, M.D.; ANTHONY V. PISCIOTTA, M.D.; CLARA V. HUSSEY, M.S.
AMA Arch Intern Med. 1955;95(1):2-14. doi:10.1001/archinte.1955.00250070018002.
Text Size: A A A
Published online

THE DISCOVERY of a case of congenital hypoprothrombinemia in 1941 by Rhoads and Fitz-Hugh 1 marked the beginning of an important advance in the study of hemorrhagic diseases. This case had been diagnosed and regarded as hemophilia for nine years. Only after the prothrombin-time test became available was it possible to differentiate such a condition readily from hemophilia. From the early studies * it became evident that cases of this type were congenital and likely familial. All were tacitly accepted as true hypoprothrombinemia. The discovery of the labile factor (proaccelerin, Factor V, or ac-globulin) in 1943 clearly demonstrated that the prothrombin time could be prolonged by a deficiency of this new factor, and the prediction that such a lack might cause a hemorrhagic disease 9 was borne out when, less than two years later, Owren 10 reported a patient with a bleeding tendency who lacked this agent. Shortly thereafter, members of

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();