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METASTATIC CALCIFICATION AND NEPHROCALCINOSIS FROM MEDICAL TREATMENT OF PEPTIC ULCER

ISIDORE SNAPPER, M.D.; WILLIAM G. BRADLEY; VERNON E. WILSON, M.D.
AMA Arch Intern Med. 1954;93(6):807-817. doi:10.1001/archinte.1954.00240300001001.
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INTEREST in the problem of the deposition of calcium in abnormal locations, that is, in subcutaneous tissue and visceral organs, has been revived by the relatively recent publication of Burnett and associates of a study of six cases of metastatic calcification related to excessive ingestion of alkali and milk in patients with ulcers of the stomach.6

GENERAL COMMENTS ON METASTATIC CALCIFICATION  Metastatic calcification may be caused by many different conditions in addition to that listed above, and the following ailments should be mentioned: ( 1) administration of excessive amounts of vitamin D; (2) hyperparathyroidism; (3) chronic renal disease in young persons, leading to long-standing acidosis; (4) complete immobilization in patients with fractures treated with extensive plaster casts or during wide-spread paralysis in poliomyelitis; (5) chronic lower nephron nephrosis or so-called tubular acidosis.17Metastatic calcification also occurs in rapidly spreading osteolytic malignant lesions of the skeleton. The tendency to metastatic

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