No one is better qualified than Dr. Snapper and his associates to write about multiple myeloma. Dr. Snapper has been interested in the subject for years, not only in connection with the myeloma cell but also in connection with bone disease in general. He also was the man who introduced stilbamidine in the treatment of myelomatosis. After an interesting historical introduction there is a chapter on the myeloma cell, and following this the subject is taken up systematically dealing with symptoms, metabolic abnormalities, pathology, differential diagnosis, and treatment. It is disappointing of course that nothing very effective is offered by Dr. Snapper. He speaks of x-ray treatment, of stilbamidine, and of urethane. None of these agents, as everyone knows, is highly effective, and multiple myeloma remains essentially an intractable and hopeless disease. Formulation of the whole subject, however, in simple and attractive format of this sort, is certainly useful.