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December 1953, Vol 92, No. 6 >
ARTICLE | December 1953

MYOGLOBINURIA

RAGNAR HED
AMA Arch Intern Med. 1953;92(6):825-832. doi:10.1001/archinte.1953.00240240061004.
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MYOGLOBINURIA is, as the name suggests, excretion of muscle coloring matter in the urine. It is not an illness sui generis but only a symptom of a disease process in the muscles, just as hematuria is indicative of a morbid change in the urogenital apparatus. One can distinguish four different types of myoglobinuria.1

  1. Traumatic myoglobinuria, which may be caused by

    • (a) Crush injury

    • (b) High voltage accident

    • (c) Arterial occlusion with ischemia

  2. Myositis myoglobinurica

  3. Haff disease

  4. Paroxysmal myoglobinuria

Crush injury is a syndrome2 which was already described in 1916, but during the last war more interest has been taken in it. In widely spread traumatic muscle injuries myoglobin may be found in the urine. Then a renal injury arises, with oliguria, isosthenuria, and azotemia. The mortality rate is high, and the patients often die on the 7th to the 10th day. By study of microscopic sections one finds the musculature discolored

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