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ARTICLE | July 1953

THE THYROID GLAND IN RELATION TO NEUROMUSCULAR DISEASE

CLARK H. MILLIKAN, M.D.; SAMUEL F. HAINES, M.D.

AMA Arch Intern Med. 1953;92(1):5-9. doi:10.1001/archinte.1953.00240190017002.

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IN 1895 Bathurst¹ described a patient who had exophthalmic goiter and severe muscle wasting. Apparently this is the first instance in which sharp attention was focused on the possible existence of a relationship between muscle function and the thyroid gland. The literature concerning this subject is not voluminous, even now. In 1938, Starling, Darke, Hunt, and Brain² suggested the following classification for a number of disorders in which thyroid and muscle dysfunction were associated:

Exophthalmic ophthalmoplegia
Thyrotoxic myopathy
- Acute thyrotoxic myopathy
- Chronic thyrotoxic myopathy
- Thyrotoxic periodic paralysis
Myasthenia gravis and thyrotoxicosis

The cases cited as evidence for the existence of "acute thyrotoxic myopathy" are few and inconclusive. The patient reported by Heuer³ in 1916 probably had thyrotoxicosis associated with myasthenia gravis. Sheldon and Walker⁴ wrote concerning acute thyrotoxic myopathy in 1946. The one patient on whom data were reported was extremely weak but was made "almost normal" by

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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MILLIKAN CH, HAINES SF. THE THYROID GLAND IN RELATION TO NEUROMUSCULAR DISEASE. AMA Arch Intern Med. 1953;92(1):5-9. doi:10.1001/archinte.1953.00240190017002.

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