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TREATMENT WITH LARGE DOSES OF PENICILLIN IN A CASE OF SEVERE BACTEREMIA DUE TO PROTEUS

BURTON A. WAISBREN, M.D.
AMA Arch Intern Med. 1953;91(1):138-141. doi:10.1001/archinte.1953.00240130146013.
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ONE OF THE current problems in the control of infection in general hospitals is the treatment of infections due to Proteus organisms. The relative resistance of these organisms to antibiotics makes it likely that they will continue to be the survivors in situations in which secondary infection is inevitable and in which prophylactic chemotherapy is employed. This case report is presented to illustrate some of the difficulties encountered in the treatment of infections due to Proteus and to emphasize the effectiveness of large doses of penicillin in certain cases.

REPORT OF CASE  The patient was a 45-year-old chronic alcoholic who was admitted to the Milwaukee County General Hospital because of a persistent low-grade fever. For 10 days prior to admission he was treated at another hospital for delirium tremens and a left lower lobe pneumonia. Treatment had consisted of administration of 3,000,000 units of procaine penicillin, 2 gm. of aureomycin,

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