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PARALLEL RELATION OF HYPERGLYCEMIA AND HYPERLIPEMIA (ESTERIFIED FATTY ACIDS) IN DIABETES

EDWIN F. HIRSCH, M.D.; BRENDAN P. PHIBBS, M.D.; LYNN CARBONARO, M.S.
AMA Arch Intern Med. 1953;91(1):106-117. doi:10.1001/archinte.1953.00240130114011.
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THE INDEX used for many years to guide the management of diabetes mellitus was the efficacy with which the excretion of glucose in the urine could be controlled. When methods for measuring the glucose content of the blood were devised, the maintenance of the sugar of the blood at normal levels became the objective. The metabolism of both carbohydrates and fats in diabetes mellitus is abnormal, and the blood of a patient with severe diabetes is hyperlipemic. The pattern of the hyperlipemias in diabetes mellitus has not been investigated because systems of blood analysis do not include methods for the fractional estimation of the lipids in small amounts of blood comparable in precision to those with which the glucose content of the blood is measured. Methods for estimating the cholesterol content of the blood have been available for many years, and clinicians have taken the cholesterol level of the blood

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