AFTER THE appearance of preliminary reports of favorable effects of aureomycin, chloramphenicol, and oxytetracycline ("terramycin") in mumps, these three broad-spectrum antibiotics were studied systematically for symptomatic effects when given early in the course of mumps orchitis. A clear demonstration of therapeutic results was considered desirable because epidemic parotitis was the most frequent infection of known viral etiology in a medical service for adults and was. often associated with distressing symptoms. Mumps orchitis was found to present a course severe enough and consistent enough to allow conclusions to be drawn from a few cases in which the symptoms persisted despite therapy.
—Tentative reports of favorable results of aureomycin therapy in mumps were made by four groups of investigators. Langley and Bryfogle 1 treated three patients with parotitis on the first, third, and seventh days of illness with symptomatic improvement four, five, and two days, respectively, after treatment was begun.