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LACK OF INFLUENCE OF PENICILLIN ON BLOOD COAGULATION

DEMOS C. TRIANTAPHYLLOPOULOS, M.D.; BURTON A. WAISBREN, M.D.
AMA Arch Intern Med. 1952;90(5):653-659. doi:10.1001/archinte.1952.00240110079008.
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THE REPORT of Moldavsky, Hasselbrock, and Cateno1 that penicillin hastened the coagulation of blood has been confirmed by some workers and denied by others. The work of Macht2 and the clinical impressions of Kemler,3 Ochsner and DeBakey,4 Frada,5 and Pelz6 supported the original findings, while the studies of Lewis,7 Weiner, Zeltmacher, and Shapiro8 and Dolkart and co-workers,9 Fleming and Fish,10 and Szczeklik and co-workers11 failed to demonstrate a significant effect on any of the coagulation mechanisms tested. Observations of Hines and Kessler,12 Axtrup,13 and Lewitus14 that in certain instances penicillin actually inhibited certain phases of coagulation have not been confirmed by other workers.9c

Although editorials and review articles have emphasized that the question of an effect of penicillin on blood coagulation has yet to be settled, certain textbooks already have warned against the use of penicillin because of its supposed effect on coagulation.1" The present study was done to determine

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