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AMA Arch Intern Med. 1952;90(1):54-63. doi:10.1001/archinte.1952.00240070060006.
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NYGAARD and Brown1 in 1937 reported five cases of vascular disease characterized by recurrent episodes of acute occlusions in the large and small arteries of the extremities, heart, kidney, and brain. The findings did not conform to those of the well-known groups of vascular syndromes. It was reported that the occlusive attacks were commonly preceded by localized or migrating thromboses of the superficial or deep veins. The symptoms were directly related to the vascular occlusions, and gangrene of the extremities was frequently observed. Histologic study of the affected vessels indicated a slight cellular reaction in the walls of the vessels and the absence of degenerative or inflammatory vascular disease. Four of the patients studied showed evidence of increased coagulability of the blood during thrombotic episodes. In two patients, elevation of the blood globulins and fibrinogen was observed. This finding was interpreted to be of importance in reducing the suspension


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