RESTRICTION of sodium intake in the form of a salt-poor diet has become an accepted form of therapy for various disease entities. These include particularly congestive heart failure, attacks of pulmonary edema, the nephrotic syndrome, and hepatic disease with ascites.
It is no easy task to prepare a varied and palatable diet which contains only 1 to 2 gm. of sodium chloride. Few patients will tolerate the monotonous, tasteless low-sodium diet for more than brief intervals. Any means which would permit these patients to ingest a diet containing a reasonable amount of sodium chloride, and yet enable them to excrete the ingested sodium without difficulty, would be a welcome solution to this problem. The use of cation-exchange resins has been suggested as a method of accomplishing this.
In 1946 Dock fed a hydrogen-cation exchanger to rats to obtain sodium depletion.1 In 1947 Gilwood suggested the use of an ammonium