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USE OF CORTICOTROPIN AND CORTISONE IN ACUTE HOMOLOGOUS SERUM HEPATITIS

HAROLD RIFKIN, M.D.; LEON J. MARKS, M.D.; DAVID J. HAMMERMAN, M.D.; MORTIMER J. BLUMENTHAL, M.D.; ALTER WEISS, M.D.; BERTHOLD WEINGARTEN, M.D.
AMA Arch Intern Med. 1952;89(1):32-40. doi:10.1001/archinte.1952.00240010042004.
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THE ABILITY of the physician to treat liver disease on any rational basis has probably made little progress in the last century.1 The doctor's resources in the therapy of acute hepatitis include rest in bed, forced high-protein and high-carbohydrate intake, administration of lipotropic agents, liver extract, and multiple vitamins, and parenteral fluid alimentation, including use of salt-poor albumin.2 With early diagnosis and institution of therapy, many patients will recover from the acute stage of the disease. Experience has demonstrated, however, that a number of these patients will die of an acute rapidly progressive hepatitis and cholemia. These patients usually become anorectic, with severe nausea and vomiting. Parenteral alimentation becomes difficult, especially when the patient is confused and disoriented. It is imperative, therefore, to obtain some agent which will provide support until the liver can repair itself. Eppinger in Europe3 and recently Webster4 in this country have utilized adrenal cortex extract

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