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EFFECT OF CORTICOTROPHIN AND CORTISONE ON THE BLOOD IN VARIOUS DISORDERS IN MAN

M. M. WINTROBE, M.D.; G. E. CARTWRIGHT, M.D.; J. G. PALMER, M.D.; W. J. KUHNS, M.D.; L. T. SAMUELS, Ph.D.
AMA Arch Intern Med. 1951;88(3):310-336. doi:10.1001/archinte.1951.03810090041004.
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SINCE the discovery that corticotrophin (ACTH) and cortisone exert beneficial effects on a wide variety of disease processes which had not been considered previously to be primarily hormonal in nature, a number of patients with disorders of the blood have been treated with these agents. This report describes our own studies in 40 cases. A preliminary report of the observations on 24 of these cases has been published.1 It is now well known that lymphopenia and neutrophilia develop in experimental animals2 and in man3 after administration of corticotrophin. The reduction in circulating eosinophils which follows administration of corticotrophin has been used as a test for adrenal-cortical insufficiency.4 Alterations have also been produced by corticotrophin and cortisone in various disease processes involving the leucocytes. Thus, improvement after corticotrophin therapy has been seen in a number of cases of acute leukemia, with "complete" temporary remissions in some. Improvement

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