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EOSINOPHILIC GRANULOMA WITH MULTIPLE OSSEOUS AND SOFT-TISSUE LESIONS IN AN ADULT

NORMAN B. McCULLOUGH, Ph.D., M.D.
AMA Arch Intern Med. 1951;88(2):243-251. doi:10.1001/archinte.1951.03810080111011.
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THE POSTULATION that Hand-Schüller-Christian disease, Letterer-Siwe disease, and eosinophilic granuloma of bone are related and may represent different manifestations of the same fundamental disease process has been advanced by many. Since the excellent discussion on this subject by Jaffe and Lichtenstein1 most writers have accepted this view. Whether there is among the conditions which have been described as eosinophilic granuloma of the skin a single disease entity bearing any relation to eosinophilic granuloma of bone is uncertain. This question has recently been well discussed.2

In contradistinction to Hand-Schüller-Christian disease and Letterer-Siwe disease, eosinophilic granuloma of bone has until recently been regarded as limited to the skeleton. In 1947 Curtis and Cawley3 presented a case which they regarded as one of eosinophilic granuloma of bone with cutaneous manifestations. This case was that of a 16-mo.-old girl who showed on roentgen examination osseous lesions in a rib, the left

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