August 1951, Vol 88, No. 2 >

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ARTICLE | August 1951

EFFECTS OF "ARTISONE" ACETATE AND CORTISONE IN PATIENTS WITH RHEUMATOID ARTHRITIS

AARON M. LEFKOVITS, M.D.; H. J. SCHUPBACH, M.D.

AMA Arch Intern Med. 1951;88(2):201-206. doi:10.1001/archinte.1951.03810080069007.

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IN THE SEARCH for substances which would induce remission of the symptoms and signs in patients with rheumatoid arthritis in a manner similar to that obtained with cortisone and corticotrophin (ACTH), Seifter and associates¹ introduced "artisone" acetate (21-acetoxypregnenolone). These investigators observed the effect of several substances on the permeability of the synovial membrane of the ankle joints of rabbits.² Measuring the interval which elapsed between the time of injection of phenolsulfonphthalein into the synovial cavity of the ankle joints in these animals and the time of appearance and concentration of the dye in the urine, they found that systemically administered hyaluronidase and desoxycorticosterone acetate (DOCA) markedly reduced this interval and increased the rate of concentration of the dye in the urine, while cortisone, corticotrophin, "artisone," and alarm reactions induced by colchicine decidedly increased this interval and decreased the concentration of the dye in the urine. They interpreted their

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LEFKOVITS AM, SCHUPBACH HJ. EFFECTS OF "ARTISONE" ACETATE AND CORTISONE IN PATIENTS WITH RHEUMATOID ARTHRITIS. AMA Arch Intern Med. 1951;88(2):201-206. doi:10.1001/archinte.1951.03810080069007.

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EFFECTS OF "ARTISONE" ACETATE AND CORTISONE IN PATIENTS WITH RHEUMATOID ARTHRITIS

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