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TERRAMYCIN IN TREATMENT OF HUMAN BRUCELLOSIS

VERNON KNIGHT, M.D.; FRANCISCO RUIZ SANCHEZ, M.D.; AMADO RUIZ SANCHEZ, M.D.
AMA Arch Intern Med. 1951;87(6):835-843. doi:10.1001/archinte.1951.03810060064007.
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CONVINCING evidence is now available to indicate that aureomycin and chloramphenicol are effective in suppressing the acute manifestations of brucellosis.1 Substantial numbers of patients have had prompt clinical remissions of the acute illness following treatment with both these agents. Despite improvement in treatment of the acute infection, however, there remains a serious therapeutic problem in the occurrence of an appreciable number of relapses. In the several series reported, including those described by us, the rate of relapse has ranged from less than one fourth to approximately one half of the total patients treated. Among the many factors which may influence the relapse rate is one common to virtually all the aforementioned studies, namely, a limitation of the total length of antimicrobial therapy to a period of about two weeks or less. In these various studies the regimens of therapy were principally determined by the amount of drug available, and

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