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Extrinsic Factors in Carcinogenesis.

AMA Arch Intern Med. 1951;87(5):773. doi:10.1001/archinte.1951.03810050151015.
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This publication presents the report of a fairly extensive study of the "tumor acceleration phenomenon" induced by known and suspected carcinogens. The author defines the acceleration phenomenon as "an increase of the incidence and/or a reduction of the age of appearance of the tumors."

Along with the report of the results obtained from his own investigations, the author presents a comprehensive review of the pertinent literature and a critical appraisal of the reports made by other investigators.

Suspected carcinogens from dietary sources were studied, but no significant evidence was obtained that would warrant the recommendation of a radical change in the diet or mode of living now followed by civilized nations. However, it does appear from this study that retardation in the incidence and growth of cancer might follow a restriction of certain luxuries and a moderate quantitative reduction of diet, particularly at the cost of fatty substances, in persons


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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