ALTHOUGH Simmonds1 was the first to describe a clear relationship between a destructive lesion of the anterior lobe of the pituitary gland and the clinical syndrome resulting from such a lesion, others2 previously had described cases with a similar clinical picture. These writers considered the clinical symptoms to be a result of polyglandular deficiency but failed to recognize that a destructive lesion of the adenohypophysis was primary and that the atrophic change in the adrenal glands, thyroid and gonads was secondary. Clinical panhypopituitarism, long known as Simmonds' disease, follows destruction of the anterior lobe of the pituitary gland. It may be brought about by a variety of pathological lesions, such as an ischemic necrosis occurring during an abnormal delivery or puerperium, by tumors, granulomas, injury, surgical hypophysectomy and "spontaneous" atrophy and fibrosis. The first is by far the commonest cause of Simmonds' disease. Although Simmonds3 and others
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and
Association With Material Stature
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dhildhood mortality and growth failure data and their association with maternal
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