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ANTISTREPTOLYSIN O RESPONSE FOLLOWING HEMOLYTIC STREPTOCOCCUS INFECTION IN EARLY CHILDHOOD

LOWELL A. RANTZ, M.D.; MARGARET MARONEY, M.D.; JOSEPH M. DI CAPRIO, M.D.
AMA Arch Intern Med. 1951;87(3):360-371. doi:10.1001/archinte.1951.03810030033003.
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HEMOLYTIC Streptococcus infections in humans beings have been intensively studied during the last 20 years particularly because of the intimate association of these disorders with acute rheumatic fever.1 The subjects of nearly all these investigations have been in one of two categories. One group has been composed of persons, usually children, in whom the rheumatic state or acute nephritis was already established.2 The other has consisted of young adults, often military personnel, in whom detailed analyses of the natural history of acute streptococcic respiratory infection and its nonsuppurative sequelae have been made.3

Surprisingly few studies have been made of the course and associated immunologic phenomena in group A Streptococcus infection in nonrheumatic infants and children, although the diseases caused by these organisms are unusual in civilian life in any age groups but these. Most important has been the report of Powers and Boisvert,4 which clearly defined the changing pattern of

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