TISSUE common observation. Weight loss, however, does not always appear early in cancer. Other signs of deranged nitrogen metabolism, such as hypoproteinemia, may persist for some time while synthesis of tissue proteins is taking place.1 The study here reported was undertaken in an attempt to explore further the shifts in nitrogen utilization occurring in patients with neoplastic disease, especially when protein hyperalimentation was employed.
—Two patients from the Third Medical Division at Bellevue Hospital, New York, were studied, the first for one period, the second for four periods. H. W. was a 51 year old Chinese man with bronchogenic carcinoma which had been diagnosed by biopsy of a supraclavicular node. There were widespread metastases to ribs, vertebrae, pelvic bones and lymph nodes. The course was rapidly downhill and the twenty-one day study period was terminated by death.The second patient, a 70 year old white man,