THE FIRST paper of this series was a report in 1942 of the relation of retinal arteriovenous nicking to the size of the heart in ambulatory hypertensive patients.1 The studies which were reported on at that time began in the late 1930's, and within the past two years my colleagues and I have had the opportunity to reexamine some of these earlier patients. During the earlier studies we made careful notes on the appearance of each lesion, in particular those of retinal arteries, so that we were able in this reexamination a decade later to note the changes in the lesion that had taken place over the years. The present report deals with the results of such examinations.
In our first paper we saw a need for careful evaluation of the various degrees of arteriovenous nicking. Prior to this time, we could find no report that the lesion varied in