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Arch Intern Med (Chic). 1948;82(2):184-195. doi:10.1001/archinte.1948.00220260074006.
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ACCORDING to most published data, pernicious anemia appears to have an uneven distribution in different parts of the world, being a disease chiefly of the temperate zone, more particularly North America, the British Isles and Northern Europe. Information concerning its incidence in the tropics is meager in the better known textbooks of medicine. In addition to this lack of knowledge, there are divergent opinions as to the role that race plays in the distribution of the disease, especially in relation to the frequency among Negroes.

From a review of the literature, the prevailing impression is gained that the incidence of the disease in Negroes is increased in proportion to the amount of intermixture with white persons. Cornell1 quoted Longcope as saying that pernicious anemia seldom if ever occurs in fullblooded Negroes. Kracke2 adhered to this same view and stated that after a careful watch for the disease at


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