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On the Morphology of Blood and Bone-Marrow in Thyrotoxicosis.

Arch Intern Med (Chic). 1947;80(5):694. doi:10.1001/archinte.1947.00220170130014.
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This monograph is a report of the condition of the blood and of the bone marrow obtained by aspiration in 24 control subjects, 26 patients with nontoxic goiter and 33 patients with thyrotoxicosis. The older literature is completely reviewed; practically no investigations have been reported on the bone marrow in thyrotoxicosis.

The patients with nontoxic goiter showed no important abnormalities. The more important deviations in the patients with thyrotoxicosis consisted of a lymphocytosis of the peripheral blood and a shift toward immaturity of the neutrophilic granulocytes and, to a lesser extent, of the normoblasts in the bone marrow. This shift was more distinct in the severely toxic forms of the disease. The described changes reverted toward normal after therapy with iodine or methylthiouracil and after thyroidectomy. The author does not feel that the inconstant and slight changes in the blood and bone marrow are of great importance in the prognosis


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