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Catgut Sterilization: The Basic Principles of the Spore-Germinating Method.

Arch Intern Med (Chic). 1947;80(1):145. doi:10.1001/archinte.1947.00220130153015.
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This monograph comprises original investigative work on a new method of sterilization of surgical gut and a historical review of methods of sterilization of surgical gut.

The author describes a new method, known as the spore germination method. The first step is to sterilize freshly softened split and looped ribbons prior to twisting, according to the method of Kuhn. The next phase of the process concerns itself with the incubation of both anaerobes and aerobes to allow germination of all spores without the appearance of new resistant elements. After the period of cultivation, complete sterilization is then effected while the maximum number of spores are present and before new resistant spores have time to be formed. The subsequent handling of the ribbons after sterilization proceeds under simple aseptic precautions in properly equipped premises, followed by a mild after-sterilization.

The author claims that by means of this method it is possible


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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