ACCORDING to a recently presented concept,1 much of the symptomatology in patients with myasthenia gravis can be explained by a decreased acetylcholine synthesis. Amino acids2 and proteins3 were found to increase the acetylcholine synthesis in vitro. It seemed reasonable, therefore, to investigate the effect of the infusion of amino acids on patients with myasthenia gravis.
Records of muscle action potential were taken from healthy subjects and from patients with myasthenia gravis by the following method: The forearm was firmly fixed in the supine position onto a padded board by means of broad strips placed across the arm near the elbow and the wrist. Of the two silver recording electrodes (0.5 sq. cm.), one was fixed with adhesive tape to the skin over the ventral surface of the first phalanx of the fifth finger and the other over the surface of the hypothenar eminence at a distance