THE SURGICAL removal of one or more lobes of the lungs is now the accepted treatment for chronic suppurative bronchiectasis. About half the patients who suffer from this dreadful ailment are unable to undergo operation, however, because their lesions are too extensive or because they are poor surgical risks. I have sought to determine whether local penicillin therapy would help control the infectious element in the disease and thus reduce the amount of sputum in the nonsurgical and surgical patients. It was not anticipated that the drug would in any way affect the anatomic deformity of the bronchial tree.
A 62 year old dentist with bronchiectasis of the lower lobe of the left lung presented himself at the Mount Sinai Hospital in June 1944 (case 1). His illness started two and one-half years earlier with suppurative bronchopneumonia, and, after a continual febrile course for eighteen months, he had been sent