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PENICILLIN IN THE TREATMENT OF KERATOSIS BLENNORRHAGICA WITH POLYARTHRITIS

A. W. FREIREICH, M.D.; SHELDON SCHWARTZ, M.D.; OTTO STEINBROCKER, M.D.
Arch Intern Med (Chic). 1947;79(2):239-250. doi:10.1001/archinte.1947.00220080127007.
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THE PURPOSE of this communication is to present our observations on 3 cases of keratosis blennorrhagica treated with penicillin. To our knowledge, no record of this type of therapy for keratosis blennorrhagica has appeared so far in the literature. It is a rare condition, occurring approximately in the ratio of 1 in every 5,000 to 7,500 cases of gonorrhea.1 To date, somewhat over 100 cases have been reported.

Many excellent reviews2 of this disease have been published, and we shall not go into a detailed description of the lesions. The clinical syndrome is characterized by the triad of urethritis, arthritis and dermatosis.3 The onset is insidious and follows chronic and recurrent attacks of gonorrheal urethritis. Chills and fever are present. The dermatitis is usually preceded by or associated with arthritis involving one or several joints. The lesions of the skin consist of vesicles, pustules and crusting associated with keratosis. The nails

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