IT IS the purpose of this report to describe certain features of induced malaria as observed in the treatment of 243 patients with neurosyphilis. The establishment by the Surgeon General of a center for the treatment of neurosyphilis in a hospital to which numerous patients with naturally acquired malaria had been admitted from overseas provided a unique opportunity to study the transmission of Plasmodium vivax malaria under controlled conditions. It also afforded a means of observing the untreated primary malarial attack with respect to symptoms, complications, course, response to antimalarial therapy and rate of relapse.
MATERIAL AND METHODS
The 243 patients included in this study were suffering from asymptomatic (77 per cent) or symptomatic (23 per cent) neurosyphilis. One hundred and seventy-five of these patients were white and comprised the chief group for study. The remaining 68 patients were Negroes; 45 of these were given quartan malaria, and an effort