SINCE Saxl and Heilig1 introduced the organic mercurial diuretics into the treatment of cardiac edema, many studies have been reported concerning their mechanism of action. The renal action of these diuretics has been proved by experiments on the isolated heart-lung-kidney preparation (Gremels2) and by observations on transplanted kidneys (Govaerts3). Investigations using the creatinine clearance method on dogs (Schmitz4) and on men (Herrmann and his colleague5) showed that the administration of these diuretics effected a diminished tubular reabsorption.
Evidence for an extrarenal action of the organic mercurial diuretics has also been brought forward, but is less convincing. The method usually employed when this problem of renal as against extrarenal action of mercurial diuretics is investigated is to examine the fluctuations in hemoglobin content or hematocrit values, total plasma protein and plasma volume during diuresis. It is reasoned that a primary extrarenal action of these drugs, effecting
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 10
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.