IT has been known for many years that pressure on the neck over the carotid artery produces slowing of the heart. Parry1 in 1799 described a retardation of the heart in man by pressure over one carotid artery. Waller2 in 1862 made similar observations. Czermack3 in 1866 attributed the slowing of the heart to mechanical stimulation of the vagus nerve. Many observations were reported on the effects on the cardiac mechanism of pressure over the carotid sheaths, and the test was called the vagus pressure test. It was not until 1927, with the publication of Hering's excellent monograph,4 that it was definitely demonstrated that the vagus nerve was not affected directly but that pressure over the carotid sheath stimulated sensory endings in the carotid sinus, which resulted in reflex cardiac inhibition and other reflex effects.
The brilliant investigations of Hering,4 Heymans5 and Koch6 established the function of the
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 59
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.